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Hepatic focal nodular hyperplasia

MedGen UID:
90733
Concept ID:
C0333980
Disease or Syndrome
Synonyms: Focal Nodular Hyperplasia; Focal Nodular Hyperplasias; Hyperplasia, Focal Nodular; Hyperplasias, Focal Nodular
SNOMED CT: Focal nodular hyperplasia (22995004)
 
HPO: HP:0034498

Definition

Hepatic focal nodular hyperplasia (FNH) is a benign hepatic tumor. FNH develops within hepatic parenchymal tissue that is otherwise histologically normal. Macroscopically, the tumor is characterized by the presence of depressed, grayish-white scar, which is generally (but not always) located at the center of the lesion, with fibrous septa radiating outward, toward the periphery of the tumor. This stellate scar is found in only 50% of all FNH nodules, but its presence is regarded as pathognomonic. The lesion itself is usually lighter in color than the tissue that surrounds it, and it sometimes has a yellowish hue. FNH nodules are generally not capsulated; their margins are well defined, and they are sometimes lobulated. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic focal nodular hyperplasia

Professional guidelines

PubMed

Choi BY, Nguyen MH
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Recent clinical studies

Etiology

Zhang G, Wang M, Duan F, Yuan K, Li K, Yan J, Chang Z
Diagn Interv Radiol 2017 Jan-Feb;23(1):66-70. doi: 10.5152/dir.2016.16061. PMID: 27910813Free PMC Article
Pillon M, Carucci NS, Mainardi C, Carraro E, Zuliani M, Chemello L, Calore E, Tumino M, Varotto S, Toffolutti T, Destro R, Gazzola MV, Alaggio R, Basso G, Messina C
Bone Marrow Transplant 2015 Mar;50(3):414-9. Epub 2015 Jan 12 doi: 10.1038/bmt.2014.276. PMID: 25581411
Dohan A, Soyer P, Guerrache Y, Hoeffel C, Gavini JP, Kaci R, Boudiaf M
J Comput Assist Tomogr 2014 Jan-Feb;38(1):96-104. doi: 10.1097/RCT.0b013e3182a91006. PMID: 24424559
Liu QY, Zhang WD, Lai DM, Ou-Yang Y, Gao M, Lin XF
World J Gastroenterol 2012 Dec 21;18(47):7048-55. doi: 10.3748/wjg.v18.i47.7048. PMID: 23323007Free PMC Article
Rogers JV, Mack LA, Freeny PC, Johnson ML, Sones PJ
AJR Am J Roentgenol 1981 Nov;137(5):983-90. doi: 10.2214/ajr.137.5.983. PMID: 6975026

Diagnosis

Giambelluca D, Taibbi A, Midiri M, Bartolotta TV
Abdom Radiol (NY) 2019 Mar;44(3):1183-1184. doi: 10.1007/s00261-018-1852-1. PMID: 30488100
Dioguardi Burgio M, Ronot M, Salvaggio G, Vilgrain V, Brancatelli G
Semin Ultrasound CT MR 2016 Dec;37(6):511-524. Epub 2016 Aug 12 doi: 10.1053/j.sult.2016.08.001. PMID: 27986170
Zeina AR, Glick Y
Ann Hepatol 2016 Nov-Dec 2016;15(6):929-931. doi: 10.5604/16652681.1222112. PMID: 27740528
Cho Y, Shimono T, Morikawa H, Shintaku H, Tokuhara D
Pediatr Int 2014 Dec;56(6):e102-e105. doi: 10.1111/ped.12456. PMID: 25521987
Liu QY, Zhang WD, Lai DM, Ou-Yang Y, Gao M, Lin XF
World J Gastroenterol 2012 Dec 21;18(47):7048-55. doi: 10.3748/wjg.v18.i47.7048. PMID: 23323007Free PMC Article

Therapy

Cattoni A, Rovelli A, Prunotto G, Bonanomi S, Invernizzi P, Perego R, Mariani AM, Balduzzi A
Pediatr Blood Cancer 2020 Apr;67(4):e28137. Epub 2019 Dec 30 doi: 10.1002/pbc.28137. PMID: 31889398
Xu R, Wang J, Huang X, Zhang Q, Xie Y, Pang L, Bai L, Zhou J
J BUON 2019 Jul-Aug;24(4):1429-1434. PMID: 31646787
Zhang G, Wang M, Duan F, Yuan K, Li K, Yan J, Chang Z
Diagn Interv Radiol 2017 Jan-Feb;23(1):66-70. doi: 10.5152/dir.2016.16061. PMID: 27910813Free PMC Article
Zeina AR, Glick Y
Ann Hepatol 2016 Nov-Dec 2016;15(6):929-931. doi: 10.5604/16652681.1222112. PMID: 27740528
Pillon M, Carucci NS, Mainardi C, Carraro E, Zuliani M, Chemello L, Calore E, Tumino M, Varotto S, Toffolutti T, Destro R, Gazzola MV, Alaggio R, Basso G, Messina C
Bone Marrow Transplant 2015 Mar;50(3):414-9. Epub 2015 Jan 12 doi: 10.1038/bmt.2014.276. PMID: 25581411

Prognosis

Cattoni A, Rovelli A, Prunotto G, Bonanomi S, Invernizzi P, Perego R, Mariani AM, Balduzzi A
Pediatr Blood Cancer 2020 Apr;67(4):e28137. Epub 2019 Dec 30 doi: 10.1002/pbc.28137. PMID: 31889398
Gürses C, Okşar FS, Erol B, Yalçın M, Kahvecioğlu N, Alparslan AŞ
Turk J Gastroenterol 2017 Nov;28(6):492-497. Epub 2017 Oct 25 doi: 10.5152/tjg.2017.17227. PMID: 29086718
Zeina AR, Glick Y
Ann Hepatol 2016 Nov-Dec 2016;15(6):929-931. doi: 10.5604/16652681.1222112. PMID: 27740528
Pillon M, Carucci NS, Mainardi C, Carraro E, Zuliani M, Chemello L, Calore E, Tumino M, Varotto S, Toffolutti T, Destro R, Gazzola MV, Alaggio R, Basso G, Messina C
Bone Marrow Transplant 2015 Mar;50(3):414-9. Epub 2015 Jan 12 doi: 10.1038/bmt.2014.276. PMID: 25581411
Cho Y, Shimono T, Morikawa H, Shintaku H, Tokuhara D
Pediatr Int 2014 Dec;56(6):e102-e105. doi: 10.1111/ped.12456. PMID: 25521987

Clinical prediction guides

Gürses C, Okşar FS, Erol B, Yalçın M, Kahvecioğlu N, Alparslan AŞ
Turk J Gastroenterol 2017 Nov;28(6):492-497. Epub 2017 Oct 25 doi: 10.5152/tjg.2017.17227. PMID: 29086718
Zeina AR, Glick Y
Ann Hepatol 2016 Nov-Dec 2016;15(6):929-931. doi: 10.5604/16652681.1222112. PMID: 27740528
Cho Y, Shimono T, Morikawa H, Shintaku H, Tokuhara D
Pediatr Int 2014 Dec;56(6):e102-e105. doi: 10.1111/ped.12456. PMID: 25521987
Bartolotta TV, Taibbi A, Brancatelli G, Matranga D, Tumbarello M, Midiri M, Lagalla R
Radiol Med 2014 Apr;119(4):222-30. Epub 2013 Dec 3 doi: 10.1007/s11547-013-0333-4. PMID: 24297582
Liu QY, Zhang WD, Lai DM, Ou-Yang Y, Gao M, Lin XF
World J Gastroenterol 2012 Dec 21;18(47):7048-55. doi: 10.3748/wjg.v18.i47.7048. PMID: 23323007Free PMC Article

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